Name: Chicken Alfredo Lasagna Recipe
Prep time: 30 min
Cook time: 1 h 10 min
Total time: 1 h 40 min
Cuisine: Italian
Ingredients: ¼ cup butter; ¼ cup all-purpose flour; 5-6 cloves garlic, minced; 1 tablespoon Italian seasoning; 1 tablespoon chicken base (or 3 bouillon cubes); 1 teaspoon onion powder; 4 cups heavy cream; 1 ½ cups grated Parmesan cheese; Salt and pepper, to taste; 1 box lasagna noodles (traditional dried or no-boil); 3 cups chopped cooked chicken; 15 ounces whole-fat ricotta cheese; 15 ounces frozen chopped spinach (thawed and well-drained); 4 cups shredded mozzarella cheese; Fresh basil; Nutmeg; Crushed red pepper flakes

Jump to Recipe· 3.8 from 1 review

If you are craving a comforting, creamy, and utterly satisfying dinner, this Chicken Alfredo Lasagna Recipe will become your new best friend in the kitchen. Imagine layers of tender lasagna noodles embracing rich Alfredo sauce, tender chunks of chicken, and a luscious ricotta-spinach filling, all topped with bubbly mozzarella and Parmesan cheese. It’s indulgence and homestyle goodness baked to perfection, perfect for sharing with family or impressing guests. This dish brings together classic Italian flavors with the creamy comfort that everyone adores, making it a true crowd-pleaser that you’ll want to make again and again.

Ingredients You'll Need

A white rectangular baking dish filled with an uncooked layered dish topped with a thick layer of shredded cheese. Beneath the cheese, visible in some spots, is a creamy white sauce mixed with small bits of green herbs and chunks of cooked chicken, showing a creamy texture. The dish sits on a white marbled surface with a clear glass measuring cup and a small bowl with white mixture in the blurry background. Photo taken with an iphone --ar 4:5 --v 7

This Chicken Alfredo Lasagna Recipe calls for a handful of simple but indispensable ingredients, each contributing to the harmony of flavor and texture in the final dish. From creamy cheeses to fragrant seasonings, every element plays a vital role in crafting this decadent lasagna.

Butter (¼ cup): The base for your roux, giving the Alfredo sauce its luscious thickness and a silky mouthfeel.
All-purpose flour (¼ cup): Acts alongside butter to create a velvety roux that thickens the sauce perfectly.
Garlic (5-6 cloves, minced): Infuses the sauce with warm aromatic depth that makes each bite irresistible.
Italian seasoning (1 tablespoon): A blend of herbs that adds that signature Italian flair and autumnal earthiness.
Chicken base (1 tablespoon) or bouillon cubes (3): Boosts the savory umami, intensifying the chicken flavor beautifully.
Onion powder (1 teaspoon): Subtle sweetness and complexity without overpowering the sauce.
Heavy cream (4 cups): The star of the sauce providing incredible richness and a creamy texture.
Parmesan cheese (1 ½ cups, grated): Melts into the sauce for a nutty, salty finish that elevates every spoonful.
Salt and pepper: Basic seasonings to balance and highlight all the flavors.
Lasagna noodles (1 box): Use either traditional dried or no-boil sheets to hold all the layers together.
Chopped cooked chicken (3 cups): Tender, juicy pieces that provide protein and hearty texture.
Ricotta cheese (15 ounces, whole-fat): Creamy, mild cheese that blends perfectly with spinach to complement the Alfredo sauce.
Frozen chopped spinach (15 ounces, thawed and well-drained): Adds vibrant color, nutrients, and a gentle earthiness to the ricotta filling.
Mozzarella cheese (4 cups, shredded): Melts into golden, gooey goodness, topping the lasagna with cheesy bliss.
Optional add-ins: Fresh basil, nutmeg, or crushed red pepper flakes to add your own special touch to the ricotta mixture.

How to Make Chicken Alfredo Lasagna Recipe

Step 1: Make the Alfredo Sauce

Start by warming a large sauté pan over medium heat and melting the butter. Whisk in the flour to create a roux—the thickening base for your sauce. Let it cook for a couple of minutes to remove any raw flour taste. Add minced garlic, stirring enthusiastically to release its intoxicating aroma, then sprinkle in the Italian seasoning, chicken base, and onion powder. Pour in the heavy cream and bring everything to a gentle simmer. As it thickens, fold in the grated Parmesan cheese until the sauce reaches a velvety, rich consistency. Taste and adjust salt and pepper as needed, then set aside this decadent sauce.

Step 2: Cook the Pasta (if needed)

If using traditional dried lasagna noodles, bring a large pot of salted water to a rolling boil. Gently add the noodles and cook according to package instructions until al dente, which means tender but still firm to the bite—perfect for holding layers without becoming mushy. Once cooked, carefully lift the noodles out, laying them flat on a clean surface to cool and prevent sticking. No-boil noodles skip this step, making assembly that much quicker.

Step 3: Make the Spinach Ricotta Filling

In a medium bowl, combine the whole-fat ricotta cheese with spinach that has been thoroughly thawed and pressed to remove any excess water. This step is crucial to prevent your lasagna from becoming watery. Season the mixture generously with salt and pepper, and if you want to add a little magic, consider tossing in a pinch of nutmeg, some crushed red pepper flakes, or fresh basil. Stir everything together gently until creamy and well combined.

Step 4: Preheat Oven and Prepare Baking Dish

Set your oven to 350°F (175°C) to ensure it's ready when your layers are assembled. Grab a 9 x 13 inch baking dish, which is the perfect size for this recipe, allowing each layer of lasagna to build up beautifully without overflowing.

Step 5: Assemble the Lasagna

Start by spreading a thin layer of Alfredo sauce on the bottom of the baking dish—this keeps your noodles from sticking and adds creamy flavor from the first bite. Lay down three noodles side by side, then layer on 1 cup of chopped chicken, 1 cup of the ricotta-spinach filling, and 1 ¼ cups of shredded mozzarella. Spoon about a third of the remaining Alfredo sauce over the top. Repeat this layering process two more times, ending with a final layer of noodles, Alfredo sauce, and a generous melt-ready topping of mozzarella cheese. For a polished finish and best texture, put the Alfredo sauce down before the last mozzarella layer, but this is a flexible step and won’t affect the deliciousness.

Step 6: Bake to Perfection

Cover your beautifully layered lasagna with foil, sealing it tight to keep the moisture in. Pop it in the oven for 30 minutes, allowing all those flavors to meld and the dish to heat through evenly. Then, remove the foil carefully and bake uncovered for an additional 15 to 20 minutes until the cheese is golden, bubbly, and irresistibly inviting along the edges.

How to Serve Chicken Alfredo Lasagna Recipe

The image shows a white rectangular baking dish filled with a creamy baked casserole. The top layer is golden brown with small browned spots and has a melted, slightly bubbly cheese texture. Small green parsley leaves are scattered evenly across the surface, adding a fresh touch to the warm, creamy top. The casserole looks rich with a smooth, creamy sauce beneath the cheese layer. The baking dish sits on a white marbled surface. photo taken with an iphone --ar 4:5 --v 7

Garnishes

To elevate your serving presentation, sprinkle freshly chopped basil or a dash of cracked black pepper on top of the lasagna just before serving. This adds a pop of color and a burst of freshness that contrasts beautifully with the creamy layers inside.

Side Dishes

For a balanced meal, serve the lasagna alongside a crisp green salad tossed with a zesty vinaigrette or some roasted garlic asparagus. The freshness and slight acidity from these sides provide a delightful counterpoint to the rich, cheesy main course.

Creative Ways to Present

Want to make dinner feel extra special? Try individual mini lasagnas baked in ramekins for personalized portions. Alternatively, a buffet-style setup where guests serve themselves lets the beautiful layers and textures shine, making the meal interactive and fun.

Make Ahead and Storage

Storing Leftovers

Your Chicken Alfredo Lasagna Recipe keeps wonderfully in the refrigerator for 3 to 4 days. Cover it tightly with plastic wrap or foil to prevent drying out and to keep all those layers flavorful and moist when you reheat.

Freezing

This lasagna freezes well and is great for meal prepping. Store in an airtight container or wrap tightly with foil and plastic wrap to avoid freezer burn. Freeze for up to 3 months. When ready to enjoy, thaw overnight in the refrigerator for best results before reheating.

Reheating

To reheat, bake the lasagna covered in foil at 350°F (175°C) for about 25-30 minutes, or until warmed through. Removing the foil during the last 5 minutes helps to refresh that inviting golden cheese topping.

FAQs

Can I use leftover rotisserie chicken for this recipe?

Absolutely! Using leftover rotisserie chicken adds convenience and wonderful flavor to your Chicken Alfredo Lasagna Recipe. Just chop it up and layer away.

Is it necessary to drain the spinach well?

Yes, squeezing out excess moisture from the spinach is crucial to avoid a watery lasagna and to maintain the proper texture for the ricotta filling.

Can I make this recipe vegetarian?

To make a vegetarian version, simply omit the chicken and consider adding mushrooms or sautéed vegetables like zucchini or bell peppers for added heartiness.

What type of cheese works best for this recipe?

Whole-fat ricotta, shredded mozzarella, and freshly grated Parmesan are ideal for balance, creaminess, and flavor. Using pre-shredded cheeses is convenient but fresh cheeses will enhance the texture and taste.

Can I prepare the lasagna the day before baking?

Yes, assembling the lasagna a day in advance is a time-saver. Keep it covered in the refrigerator and bake when ready. It may need a little extra time in the oven if chilled.

Final Thoughts

This Chicken Alfredo Lasagna Recipe is a heartfelt, cozy dish that brings everyone to the table with smiles and full plates. Its creamy sauce, tender chicken, and cheesy layers make it an all-time favorite you’ll be reaching for anytime you want to impress without stress. I encourage you to dive into this recipe soon — your taste buds and loved ones will thank you!

Chicken Alfredo Lasagna Recipe

Ingredients You'll Need